Molecular and structural mechanism of cellular signaling proteins including G protein-coupled receptor signaling molecules
Education
(Ph.D.)Molecular and Cellular Pharmacology, University of Wisconsin-Madison
Experience
2008-2011: Postdoctoral Scholar, Stanford University
2012-2016: Assistant Professor, School of Pharmacy Sungkyunkwan University
2017-present: Associate Professor, School of Pharmacy Sungkyunkwan University
Journal Articles
(2024)
Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq.
COMMUNICATIONS BIOLOGY.
7,
(2024)
Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors.
SCIENCE.
383,
6678
(2023)
GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
120,
28
(2023)
Gαs slow conformational transition upon GTP binding and a novel Gαs regulator.
ISCIENCE.
26,
5
(2022)
Effect of ?-helical domain of Gi/o ? subunit on GDP/GTP turnover.
BIOCHEMICAL JOURNAL.
479,
17
(2021)
Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ ERK signaling cascade.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
118,
37
(2021)
The conformational transition during G protein-coupled receptor (GPCR) and G protein interaction.
CURRENT OPINION IN STRUCTURAL BIOLOGY.
69,
Special SI
(2021)
Conformational switch that induces GDP release from Gi.
JOURNAL OF STRUCTURAL BIOLOGY.
213,
1
(2021)
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
MOLECULAR CELL.
81,
2
(2020)
Many faces of the GPCR-arrestin interaction.
ARCHIVES OF PHARMACAL RESEARCH.
43,
9
(2020)
Crystal Structure of beta-Arrestin 2 in Complex with CXCR7 Phosphopeptide.
STRUCTURE.
28,
9
(2020)
Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family.
NATURE COMMUNICATIONS.
11,
1
(2020)
Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins.
STRUCTURE.
28,
3
(2019)
Assembly of a GPCR-G Protein Complex.
CELL.
177,
5
(2019)
Structural Mechanism of the Arrestin-3/JNK3 Interaction.
STRUCTURE.
27,
7
(2018)
Biophysical and functional characterization of Norrin signaling through Frizzled4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
115,
35
(2018)
Orthosteric and allosteric action of the C5a receptor antagonists.
NATURE STRUCTURAL & MOLECULAR BIOLOGY.
25,
6
(2017)
Structural and Functional Analysis of a beta(2)-Adrenergic Receptor Complex with GRK5.
CELL.
169,
3
Conference Paper
(2024)
Dynamic conformational change during GPCR-G protein coupling.
wcp2023.
UNITED KINGDOM
